"American companies should not enable or facilitate the Saudi government's patriarchy," Wyden wrote, adding that the Saudi system of control over women "abhorrent."
Cook's comments to NPR are the first time Apple has addressed the app after it declined to respond to INSIDER's repeated requests for comment. Google has not acknowledged repeated requests for comment.
Under Saudi Arabia's guardianship laws all women must have a male representative to decide if they can travel abroad. Absher is the digital manifestation of the system, and is where men manage much of women's lives.
The app has been downloaded 4.2 million times on the App Store and 5 million times on Google Play since launching in mid-2015, according to Apptopia.
Human Rights Watch's Rothna Begum told INSIDER: "Apple and Google have rules against apps that facilitate threats and harassment. Apps like this one can facilitate human rights abuses, including discrimination against women."
Yasmine Mohammed, a former Muslim and an outspoken critic of Saudi Arabia, said the companies are "facilitating the most archaic misogyny" and help the Saudi government to enforce "gender apartheid."
Apple and Google hosted Prince Mohammed bin Salman last year
The app raises awkward questions for Apple and Google, two of the biggest players in Silicon Valley, where tech firms have well-established links to Saudi Arabia.